Philip K Ahring Selected Research

5- (3,6- diazabicyclo(3.2.0)heptan- 6- yl)nicotinonitrile

10/2007

A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models.

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Philip K Ahring Research Topics

Disease

5	Pain (Aches) 02/2016 - 06/2004
3	Epilepsy (Aura) 12/2019 - 06/2004
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 08/2009
2	Tobacco Use Disorder (Nicotine Dependence) 01/2020 - 01/2014
2	Seizures (Absence Seizure) 01/2020 - 06/2013
2	Parkinson Disease (Parkinson's Disease) 01/2020 - 01/2014
2	Hypersensitivity (Allergy) 01/2020 - 02/2016
2	Infarction (Infarctions) 01/2019 - 01/2019
2	Stroke (Strokes) 01/2019 - 01/2019
2	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 09/2010
2	Neuralgia (Stump Neuralgia) 02/2016 - 10/2007
1	Neurodevelopmental Disorders 01/2022
1	Tremor (Tremors) 01/2020
1	Brain Diseases (Brain Disorder) 01/2020
1	Muscle Hypotonia (Hypotonia) 01/2020
1	Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 01/2019
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Dementia (Dementias) 01/2018
1	Hyperalgesia 02/2016
1	Brain Injuries (Brain Injury) 01/2016
1	Acquired Immunodeficiency Syndrome (AIDS) 10/2015
1	Schizophrenia (Dementia Praecox) 09/2010
1	Neuroblastoma 09/2010
1	Chronic Pain 09/2009
1	Inflammation (Inflammations) 09/2009
1	Abdominal Pain (Pain, Abdominal) 10/2007
1	Vomiting 10/2007
1	Nociceptive Pain 12/2006
1	Migraine Disorders (Migraine) 06/2004

Drug/Important Bio-Agent (IBA)

6	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2019 - 12/2006
5	Pharmaceutical PreparationsIBA 01/2020 - 01/2014
3	Analgesics (Analgesic Drugs)IBA 02/2016 - 12/2006
3	Formaldehyde (Formol)FDA Link 02/2016 - 12/2006
2	gamma-Aminobutyric Acid (GABA)IBA 01/2022 - 01/2016
2	Aminobutyrates (Aminobutyric Acid)IBA 01/2020 - 12/2019
2	GABA-A Receptors (GABA(A) Receptor)IBA 01/2019 - 09/2009
1	Reserpine (Serpasil)FDA Link 01/2020
1	Vigabatrin FDA Link 01/2020
1	Transaminases (Aminotransferases)IBA 01/2020
1	Dopamine (Intropin)FDA LinkGeneric 01/2020
1	AcetylcholinesteraseIBA 01/2019
1	GSK690693IBA 01/2019
1	2'-methoxy-6-methylflavoneIBA 01/2019
1	Proteins (Proteins, Gene)FDA Link 01/2019
1	FlavonoidsIBA 01/2019
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2019
1	InterleukinsIBA 01/2019
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019
1	CytokinesIBA 01/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019
1	ElacridarIBA 01/2019
1	Galantamine (Galanthamine)FDA LinkGeneric 01/2018
1	AlkaloidsIBA 01/2018
1	Acetaminophen (Paracetamol)FDA LinkGeneric 02/2016
1	Amiloride (Midamor)FDA LinkGeneric 02/2016
1	Acid Sensing Ion ChannelsIBA 02/2016
1	Morphine (MS Contin)FDA LinkGeneric 02/2016
1	Freund's AdjuvantIBA 02/2016
1	Zolpidem (Ambien)FDA LinkGeneric 01/2016
1	BenzodiazepinesIBA 01/2016
1	2- (3,5- difluorophenyl)- N- (6- ((4- fluorophenyl)methylamino)- 2- morpholino- 3- pyridyl)acetamideIBA 06/2013
1	Chlordiazepoxide (Elenium)FDA LinkGeneric 06/2013
1	Cytidine Diphosphate (CDP)IBA 06/2013
1	Dextroamphetamine (Dexedrine)FDA LinkGeneric 06/2013
1	Adenosine Monophosphate (AMP)IBA 06/2013
1	Dizocilpine Maleate (Dizocilpine)IBA 06/2013
1	maleic acid (maleate)IBA 06/2013
1	alpha7 Nicotinic Acetylcholine ReceptorIBA 09/2010
1	5- (6- (1- azabicyclo(2,2,2)oct- 3- yloxy)pyridazin- 3- yl)- 1H- indoleIBA 09/2010
1	Cholinergic ReceptorsIBA 08/2009
1	Ligand-Gated Ion ChannelsIBA 08/2009
1	MecamylamineIBA 10/2007
1	5- (3,6- diazabicyclo(3.2.0)heptan- 6- yl)nicotinonitrileIBA 10/2007
1	epibatidineIBA 12/2006
1	octaneIBA 12/2006
1	Nicotine FDA Link 12/2006
1	LigandsIBA 12/2006
1	Kainic Acid (Kainate)IBA 06/2004
1	Glutamate Receptors (Glutamate Receptor)IBA 06/2004
1	Glutamic Acid (Glutamate)FDA Link 06/2004

Therapy/Procedure

1	Analgesia 09/2009
1	Ligation 10/2007